Some days after my treatment I feel fatigued and some days I have a good amount of energy. I have tried many medications, with only minor results (including TMS). I have done esketamine as both IV and Spravato. I have an appointment tomorrow for another treatment. I have had no relief from my depression. If you think this is just a way to get high your wrong. If you clean your sinuses before your visit it's effects are a lot stronger. Otherwise this drug has worked very well for me in certain areas. It took 4 minutes to kick in. After going through the initial 8 week transition, I was in for Spravato almost every other week where I was in for IV once a month to as long as every 6 weeks. I am 36, and have had depression since I was 12. They will come and check on you. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners. I really don’t like the experience. I started to cry and then boom: sobbing, no idea who I was, where I was, visual disturbance so couldn't see correctly, was paranoid, untrusting - I have never been so terrified in all my life. It gave me a headache. With the IV treatment, my symptoms fully resolved the night of treatment. I had to find this out on my own, the Drs don't tell you much about what and what not to do when you take this medication. Experience: spray a mist of Spravato into each nostril while at the office. If you have a doctor giving you Spravato for severe anxiety- that’s insane! Felt hungover. One study showed that esketamine nasal spray plus an oral antidepressant delayed time to relapse compared with a placebo nasal spray plus an oral antidepressant; the other study showed evidence of safe long-term use of esket… The side effects are prolonged and there is no certainty that the benefits will last very long.”, Spravato (esketamine) for Depression: “I'm finding Repetitive transcranial magnetic stimulation (rTMS) more effective but I'm continuing to use both together. I started with Spravato because it only cost $520 total for all 8 visits ($55 copay and $10 for Spravato thru the J&J program).”, Spravato (esketamine): “I have been doing Spravato treatments for approximately 10 weeks (for bipolar) and I, and everyone who knows me, have seen a wonderful improvement in mood and energy. I don’t yet know if it facilitates pleasure but it does stop the death default.”, Spravato (esketamine) for Depression: “People need to understand that no one is the same and that EVERYONE will have different reactions. It took about six weeks and I've also been taking Prozac and some supplements which have also helped. That stuff is amazing. The appointments are unpleasant for me, but they are worth it for the relief. But after that I elected to stop taking Spravato. The UK National Institute for Health and Care Excellence (NICE) has ruled that it will not recommend Spravato (esketamine) nasal spray for treatment-resistant depression within the National Health Service (NHS) because of concerns over efficacy and cost effectiveness.. Esketamine, in combination with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake … IV vs. Initially I had a great amount of disassociation for the first hour, which gradually dissipated. I hate the whole experience. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The newly approved drug, esketamine, is one half of the ketamine compound By Angela Chen @chengela Mar 11, 2019, 3:45pm EDT Illustration by Alex Castro/ The Verge It was expensive and time consuming and very disappointing to have no results.”, Spravato (esketamine): “TRD (treatment resistant depression) for 30 years, have tried everything and will continue to try this. I spent one week totally alone I saw nobody except for my ride and my time in treatment. I completed 4 weeks of treatments of 84mg 2 times per week, 4 weeks of treatments one times per week and one treatment every other week. I highly suggest you have a strong support system in place beforehand because you will need it. I was crying for my mom. Was on 56mg 2x week for a month (eventually I had no immediate reaction as my body got used to the drug - lingering tiredness, so I did the treatments in the late afternoon) and have had 3 treatments with 84mg. I was crying for my mom. I heard of Spravato and was very excited to know there was a treatment out there that could work. I had sniffed a line or two and definitely enjoyed it plenty. I’ve yet to have an infusion. I started to feel sad again. Spravato is a waste of time and money. Waiting for the phase 3 trials of psylocybin to complete and I'm all in. I don’t have a strong reaction to the medication when it’s administered, just a slight disassociation with time and place that I can easily bring into perspective. The findings suggest maintenance ketamine may be a therapeutic alternative for that patient population, researchers … Amazing experience, be prepared as well as you can ahead of time because it is intense. If you want to skip the rubbish go for straight Ketamine. Everyone is different. THESE TWO COULD HAVE ABSOLUTELY NO RELATION TO EACH OTHER. A panoply of medicines, always with Cylert or Ritalin, provided a substantial modicum of relief for decades. But I am dreading it more than I did with ECT.”, Spravato (esketamine) for Depression: “I did the IV Ketamine for several months and found it very helpful, but it wore off very quickly. The day after my third treatment (first at 84 mg) I felt the darkness lifting. No but as I get more and more doses it is working longer and longer. I don’t dread my life anymore. That stuff is amazing. I could go on and on, but the point of this review is to show the lack of correlation between my experience and those of others. I believe that I may have better results with the 84mg and will be trying that dosage next week for week 2.”, Spravato (esketamine): “I began treatments with 56 mg which is four sprays using two syringes. Using ketamine or esketamine to treat depression is not a breakthrough discovery. I have now had 2 treatments with 53 mg. Esketamine nasal spray FDA approval should be finalized in March of 2019. Select one or more newsletters to continue. Wait at least 45 mins after when it wears off. This information is NOT intended to endorse any particular medication. I’m still not 100%, but so much better. Esketamine has an average rating of 5.2 out of 10 from a total of 39 ratings for the treatment of Depression. Prior to starting treatments, I had been sleeping 16+ hours a day and had little motivation to accomplish even basic self-care. Spravato (esketamine) for Depression: “I did a full month of treatments - 8 total at the 84 mg dose. Urination- yes it is more difficult on Spravato. Initially I had a great amount of disassociation for the first hour, which gradually dissipated. Good luck!”, Spravato (esketamine): “I’ve had 5 Spravato treatments so far for depression. I had to see someone else for one dosing and she left me in the room for 40 minutes by myself. Despite decades of research, the molecular mechanisms underlying depressionare poorly understood. Does it last forever? r/Spravato: Spravato is a novel esketamine-based antidepressant administered nasally, for treatment-resistant depression. Spavato's Savings Plan reduced the cost of the medicine to only a co-pay of $10 per treatment. As for me, I’ve found substantial relief for the first time ever (42 years of age). It took 4 minutes to kick in. I had to find this out on my own, the Drs don't tell you much about what and what not to do when you take this medication. You then need to wait two hours to be monitored for the effects to wear off. For me, the first 20 minutes are unpleasant, like a psychadelic trip that is a bit too strong. Hopefully, with the help of my multiple doctors, I will find a way to make ketamine or esketamine work for me over the long run. I have vomited on the higher dose, but an accompanying zofran has helped tremendously. It works best for me about 48 hours after a visit. Mixed results so far but I have hope. This will be followed by once a week or every other week as an ongoing maintenance. I have to go back to doing TMS everyday. I’ve tried different meds and none have seemed to help. We comply with the HONcode standard for trustworthy health information -. No affect on my TRD (treatment resistant depression after 1 treatment. The FDA approved the first truly new medication for major depression in decades. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. I have an appointment tomorrow for another treatment. If you have a doctor giving you Spravato for severe anxiety- that’s insane! Is Spravato (esketamine) a controlled substance? I started to cry and then boom: sobbing, no idea who I was, where I was, visual disturbance so couldn't see correctly, was paranoid, untrusting - I have never been so terrified in all my life. I felt like I was strapped to a Ferris wheel that wouldn’t stop spinning/falling really fast. I could go on and on, but the point of this review is to show the lack of correlation between my experience and those of others. This has taken the suicidal thoughts and squashed it, My depression is very little I really don't like the treatment - feeling spaced out for 45 mins. If you can’t stand - ask for help. I heard of Spravato and was very excited to know there was a treatment out there that could work. Face feet etc. I got approved to use Spravato for a year when needed and Jannsen Pharmaceutical is picking up my copay for now. Spravato is a waste of time and money. But esketamine is just now entering the market, and my clinic doesn’t anticipate having it until sometime in the fall. Spravato is for depression only. IV ketamine is not, and thus treating depression with ketamine is an off-label use. Felt extremely drunk--dissociation, severe nausea and sweating, dizziness, tiredness. FDA Approval of Esketamine. I've had high heart rate, dizzy, sickness, headaches, The BIGGEST most important part of this treatment is take no medications the night before and day of treatment, don't drink the night before or you will pay for it with super sickness and panic attacks and high heart rate. While on it I had increased suicidal ideations. Please don’t try this unless it’s your LAST resort.”, Spravato (esketamine) for Major Depressive Disorder: “Had my first Spravato treatment today. I want a cure, not games.”, Spravato (esketamine) for Depression: “Spravto Ketamine infusions worked well, that is until I developed severe UTI’s, kidney stones and a PSA level of 9.8! I was also hospitalized 2 months later with pneumonia and fluid in my lower left lung. Esketamine isn’t a miracle drug. Setting aside issues of health care economics and FDA procedures, esketamine also represents the first psychedelic treatment approved by the FDA for a psychiatric condition. After going through the initial 8 week transition, I was in for Spravato almost every other week where I was in for IV once a month to as long as every 6 weeks. The best thing is it is working! Felt hungover. Not good when you're tripping out.”. Diagnosis: MDD & CPTSD It does not assist anxiety. Going to keep going.”, Spravato (esketamine) for Depression: “I started in December and put it simply it saved my life. But verses being dead, it was worth the try!! trazodone, sertraline, Lexapro, citalopram, Xanax, Zoloft, Cymbalta, Prozac. This has led to three rounds of research over the past several years, the third being completed recently. It felt like my legs were separated from my body. The first week was like a miracle so I still have hope. I completed 4 weeks of treatments of 84mg 2 times per week, 4 weeks of treatments one times per week and one treatment every other week. I am trying to determine if these treatments are worth continuing. One week of the higher-dose treatment (3 containers) remains and, while I am not elated, the constant suicide hunger is gone. I feel sad/disappointed that this didn’t work. I hope this helps someone else.”, Spravato (esketamine): “Details: a medium intranasal dose twice a week in office for a month, followed by a high dose once a week. I have had no relief from my depression. In my bag: water bottle, crackers, hard candy, a book. Just remember that tramadol is a MAJOR interaction and both kratom and klonopin/xanax will make the Spravato less effective when using it. Drug class: miscellaneous antidepressants, Major Depressive Disorder with Acute Suicidal Ideation. It's more intense than the IV version and nowhere near as good as micro dosing mushrooms. I unfortunately did not and I think that had a negative affect on my response. I hope this helps someone.”, Spravato (esketamine): “People need to understand that no one is the same and that EVERYONE will have different reactions. My doctor was nervous. TMS did NOT work, nor did ECT or DBT. I do not feel dissociative symptoms, like with the IV, but I have significant symptoms of motion sickness. The drug is a nasal spray called esketamine, derived from ketamine—an anesthetic that has made waves for its surprising antidepressant effect. I hope this helps someone.”, Spravato (esketamine) for Depression: “I have been doing Spravato treatments for approximately 10 weeks (for bipolar) and I, and everyone who knows me, have seen a wonderful improvement in mood and energy. I will continue as long as I can stand it because I am pretty much out of options. Cutting to every two weeks soon. This is the first time I’ve felt on the path to the true me, free of the clouds. I went into appointment very upset and stressed, and coupled with the Spravato, had a dissociative episode. If you think this is just a way to get high your wrong. I’ve had 2 experiences of disassociation, which were extremely pleasant, controllable and very mild, at best.
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