2003 Nov;106(5):486-94. doi: 10.1007/s00401-003-0754-6. Ziel dieser Arbeit war es, festzustellen, ob und wann eine PCV 2-Infektion vor 1998, dem Jahr des erstmaligen Nachweises von PCV 2 in Deutschland, im Sektionsmaterial des Instituts für Pathologie der Stiftung Tierärztliche Hochschule Hannover aufgetreten ist. (3)Zentrum für Systemische Neurowissenschaften Hannover, ZSN. Rieckmann K, Pendzialek SM, Vahlenkamp T, Baums CG. Search Google Scholar for this author, R. Müller-Peddinghaus. HHS New aspects of the pathogenesis of canine distemper leukoencephalitis. However, histological screenings of these animals revealed pathological lesions, such as mild focal suppurative meningitis. 2020 May 6;6:12. doi: 10.1186/s40813-020-00150-6. 2010 Mar;18(3):124-31. doi: 10.1016/j.tim.2009.12.003. (2)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover. 1 Institut für Pathologie, Tierärztliche Hochschule Hannover, Germany. Gregor Warnecke 2. Silva LM, Baums CG, Rehm T, Wisselink HJ, Goethe R, Valentin-Weigand P. Vet Microbiol. Porcine Health Manag. Friederike Döring: Die intrazelluläre Lokalisation von Isoformen des Fibroblastenwachstumsfaktors – 2 (FGF-2). This page... Print this page. Kock C, Beineke A, Seitz M, Ganter M, Waldmann KH, Valentin-Weigand P, Baums CG. Miao Q, Baumgärtner W, Failing K, Alldinger S. Acta Neuropathol. Meurer M, Öhlmann S, Bonilla MC, Valentin-Weigand P, Beineke A, Hennig-Pauka I, Schwerk C, Schroten H, Baums CG, Köckritz-Blickwede MV, de Buhr N. Int J Mol Sci. Epub 2008 Oct 4. Institut für Pathologie der Tierärztlichen Hochschule Hannover, Bünteweg 17, D‐3000 Hannover 71, Germany. … In contrast to the virulent serotype 2 strain, the serotype 9 strain did not cause disease with clinical manifestations after intranasal administration. Corresponding Author . This site needs JavaScript to work properly. eCollection 2016. Fittipaldi N, Fuller TE, Teel JF, Wilson TL, Wolfram TJ, Lowery DE, Gottschalk M. Vet Microbiol. Phase-dependent expression of matrix metalloproteinases and their inhibitors in demyelinating canine distemper encephalitis. Comparative mRNA and miRNA expression in European mouflon (Ovis musimon) and sheep (Ovis aries) provides novel insights into the genetic mechanisms for female reproductive success. The University of Veterinary Medicine Hanover (German: Tierärztliche Hochschule Hannover, TiHo) is a university in Hanover and one of the five facilities for veterinary medicine in Germany, and the only one that remains independent.  |  Search for more papers by this author. The skin lesions were divided into four macroscopic groups: scaling (group I, n = 5), hyperkeratotic and hyperplastic plaque‐like lesions (group II, n = 14), nodular skin masses (group III, n = 16) and verrucous skin lesions (group IV, n = 2). Gregor Warnecke Institut für Herz-, Thorax-, Transplantations- und Gefäßchirurgie Medizinische Hochschule Hannover 1. Corresponding Author. Further Information. Centre National des Listeria, Institut de Microbiologie, CHUV, CH‐19 Sud 1011, Lausanne, Switzerland . Dr. med. The objective of this study was to determine the virulence of an MRP* SLY+ serotype 9 S. suis strain in comparison to an MRP+ EF+ SLY+ serotype 2 strain. Proteomics Studies on the three Larval Stages of Development and Metamorphosis of Babylonia areolata. Institut für Pathologie, Tierärztliche Hochschule Hannover, FRG. D-30559 Hannover, Germany e-mail: Send e-mail . Serotype distribution and production of muramidase-released protein, extracellular factor and suilysin by field strains of Streptococcus suis isolated in the United States. Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. COVID-19 is an emerging, rapidly evolving situation. Clinical manifestations related to meningitis, arthritis and serositis could be induced by intravenous application of this serotype 9 strain. Zusammenfassung. Clipboard, Search History, and several other advanced features are temporarily unavailable. Stiftung Tierärztliche Hochschule Hannover.  |  In the chronic phase, it is conceivable that a MMP-TIMP imbalance may be the motor for lesion progression with a simultaneous influx of CD44-positive activated immune cells. Clonal expansion of a virulent Streptococcus suis serotype 9 lineage distinguishable from carriage subpopulations. Andreas Beineke Institut für Pathologie Tierärztliche Hochschule Hannover Prof. Dr. med. In this phase, a decrease of MMP and TIMP expressions apart from MMP-11, -12, and -13 is obvious. Experimental intranasal and intravenous infections of 7-8 weeks old SPF piglets were investigated with regard to clinic and pathology. J. Pohlenz. vet. Hennig-Pauka I, Imker R, Mayer L, Brügmann M, Werckenthin C, Weber H, Menrath A, de Buhr N. Pathogens. Prevention and treatment information (HHS). Corresponding Author. Epub 2009 May 18. Zhao ZQ, Wang LJ, Sun XW, Zhang JJ, Zhao YJ, Na RS, Zhang JH. (1)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, Hannover, Germany. 2009 Nov 18;139(3-4):310-7. doi: 10.1016/j.vetmic.2009.06.024. Epub 2016 Jun 30. In conclusion, this study demonstrates that MRP* SLY+ serotype 9 strains are less virulent for growers than MRP+ EF+ SLY+ serotype 2 strains. 2019 Feb;122(2):172-186. doi: 10.1038/s41437-018-0090-1. Institut für Pathologie, Tierärztliche Hochschule Hannover, Peter Wohlsein. Beyerbach (Stiftung Tierärztliche Hochschule Hannover, Hannover, Germany) kindly provided support in statistical analysis. The program is subdivided into different seminars (modules) and receives support from speakers from Pharmaceutical and Chemical companies mainly located in Germany. 6 Kliniken, 19 Institute, 3 Fachgebiete und 3 Außenstellen gehören zur Stiftung Tierärztliche Hochschule Hannover. Intranasal immunization with a live Streptococcus suis isogenic ofs mutant elicited suilysin-neutralization titers but failed to induce opsonizing antibodies and protection. Tierärztliche Hochschule Hannover Prof. Dr. med. The present review decribes the role of CD44 antigen (CD44), the principle cell surface receptor for hyaluronate and extracellular matrix (ECM) processing enzymes (matrix metalloproteinases [MMPs]) and their inhibitors (TIMPs) in the pathogenesis of demyelination. TiHo Hannover - Institut für Pathologie Toxicologic Pathology Training Program A comprehensive Toxicologic Pathology Program is offered within the residency program of the TiHo. Gutachten: Prof. Dr. med. eCollection 2015. However, in Europe serotype 9 strains also contribute substantially to S. suis-associated invasive diseases of piglets. Please enable it to take advantage of the complete set of features! Beineke A, Puff C, Seehusen F, Baumgärtner W. Vet Immunol Immunopathol. Shen M, Di G, Li M, Fu J, Dai Q, Miao X, Huang M, You W, Ke C. Sci Rep. 2018 Apr 19;8(1):6269. doi: 10.1038/s41598-018-24645-z. In chronic lesions, CD44 expression declines together with the number of glial fibrillary acidic protein (GFAP) positive astrocytes. Streptococcus (S.) suis is an invasive porcine pathogen causing meningitis, septicemia, arthritis and other diseases. in northwestern Madagasca. Institut für Mikrobiologie und Tierseucben Direktor: Prof. Dr. W. Bisping der Tierärztlichen Hochschule Hannover Tierärztliche Hochschule, 3 Hannover, Bischofsholer Damm 15. Epub 2009 Jun 21. We are a leader in research, teaching and services in veterinary medicine and train young scientists in all areas of veterinary science. Publication History. Doctoral student . Virulence-associated gene profiling of Streptococcus suis isolates by PCR. This site needs JavaScript to work properly. Studies on pathogenesis as well as vaccine trials have focused on serotype 2 strains, which are worldwide the most prevalent among invasive isolates.  |  (3)3 Institut für Pathologie der Stiftung Tieraerztliche Hochschule Hannover, Hannover, Germany. R. Müller-Peddinghaus . A 5-year-old German-Holstein cow was presented with a swelling of the head which had been present for 3 months. NIH 2009 Jan 15;127(1-2):1-18. doi: 10.1016/j.vetimm.2008.09.023. 2016 Jul;11:941-54. doi: 10.2217/fmb-2016-0028. A. Navarro Camarro. The University of Veterinary Medicine Hannover, Foundation (TiHo) is a nationally and internationally recognized institution of higher education known for its excellence in veterinary science and its interdisciplinary focus. PMID: 12016561 DOI: 10.1055/s-2002-30116 Abstract The mode of action of probiotics is still incompletely understood. Hannover und Umgebung, Deutschland Scientific Assistant at the Institute for Experimental Pathology of the Medical School Hannover (Director: Professor Dr. U. Mohr). Vet Immunol Immunopathol. 2 Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, M. Ganter. Epub 2006 Jan 20. Please enable it to take advantage of the complete set of features! Epub 2003 Aug 15. PLoS One. Institut für Pathologie, Tierärztliche Hochschule Hannover, Bünteweg 17, D‐3000 Hannover 71, Germany . Universität Hannover, 2007. Donhauser & Schöneberger, Bingen am Rhein, Germany. andreas.beineke@tiho-hannover.de Harbor porpoises from the North and Baltic Seas exhibit a higher incidence of bacterial infections compared to whales from less polluted arctic waters. Microarray analysis reveals gene and microRNA signatures in diabetic kidney disease. Stiftung Tierärztliche Hochschule Hannover. The principal histological findings were hyperkeratosis and epidermal hyperplasia. Likewise, MMPs and TIMPs are prominently up-regulated in these lesions and are expressed mostly by astrocytes and microglia. Up-regulation of mRNA for matrix metalloproteinases-9 and -14 in advanced lesions of demyelinating canine distemper leukoencephalitis. NLM : 0511 / 953-8621 , 0511 / 953-8664 Diagnostik-Sprechstunden: Mo. Institut für Pathologie Tierärztliche Hochschule Hannover PD Dr. med. Fragen der Diagnostik: Geschäftszimmer, Tel.-Nr. Carlos Hermosilla Institut für Parasitologie (2)2 Tieraerztliche Gemeinschaftspraxis Dres. University Overview Founded in 1778, Tierärztliche Hochschule Hannover (University of Veterinary Medicine Hannover) is a non-profit public higher-education institution located in the urban setting of the large city of Hannover (population range of 500,000-1,000,000 inhabitants), Lower Saxony. (4)4 Klinik für Heimtiere, Reptilien, Zier- und Wildvoegel, Stiftung Tieraerztliche Hochschule, Hannover… (1)Institut für Pathologie, Stiftung Tierärztliche Hochschule Hannover, D-30173 Hannover, Germany.  |  Tierärztliche Hochschule Hannover Population and molecular genetic analyses of persistent right aortic arch and primary cataracts in the German Pinscher INAUGURAL-DISSERTATION zur Erlangung des Grades einer Doktorin der Veterinärmedizin - Doctor medicinae veterinariae – (Dr. med. Acta Neuropathol. Lempp C, Spitzbarth I, Puff C, Cana A, Kegler K, Techangamsuwan S, Baumgärtner W, Seehusen F. Viruses. eCollection 2019 Dec 10. In addition, in this plaque type, CD44 is expressed on the cell membrane of perivascular mononuclear cells. Author information: (1)Klinik für Rinder, Stiftung Tierärztliche Hochschule Hannover. Stiftung Tierärztliche Hochschule Hannover. Project: Effects of habitat fragmentation on parasite communities in mouse lemurs (Microcebus spp.) USA.gov. G. Trautwein. Role of Bacterial and Host DNases on Host-Pathogen Interaction during, A critical review speculating on the protective efficacies of autogenous, From Stable to Lab-Investigating Key Factors for Sudden Deaths Caused by, Vaccination with the immunoglobulin M-degrading enzyme of. 2016 Apr 4;11(4):e0152675. Aerial photography: Department of Pathology. Prevention and treatment information (HHS). 2020 Jul 25;21(15):5289. doi: 10.3390/ijms21155289. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. To study the interactions between probiotic micro-organisms and the host their effects on morphology and mucins of the intestinal mucosa were investigated. 2005 Oct;110(4):369-82. doi: 10.1007/s00401-005-1055-z. Save as PDF. Due to the central nervous system (CNS) tropism of the virus and associated neuropathological changes, demyelinating canine distemper encephalitis (CDE) represents a relevant model for human demyelinating diseases like multiple sclerosis. Institut für Pathologie, Tierärztliche Hochschule, Bunteweg 17, D‐30559 Hannover, Germany. Bibliografische Informationen der Deutschen Bibliothek Die Deutsche Bibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie; Detaillierte bibliografische Da Dr. med. 2019 Oct 10;3:100046. doi: 10.1016/j.jvacx.2019.100046. Epub 2010 Jan 12. Mol Med Rep. 2018 Feb;17(2):2161-2168. doi: 10.3892/mmr.2017.8177. Would you like email updates of new search results? Institute of Pathology, Section of Immunopathology and Institute of Virology, School of Veterinary Medicine, Hannover. Search for more papers by this author. Alldinger S, Fonfara S, Kremmer E, Baumgärtner W. Acta Neuropathol. eCollection 2020. J. In acute and subacute CDE, a plaque-associated CD44 up-regulation is found that parallels astrocyte activation. Center for Systems Neuroscience, Stiftung Tierärztliche Hochschule Hannover, Medizinische Hochschule Hannover, ... Bedeutung für die molekulare Pathologie der Spinalen Muskelatrophie. Medizinische Hochschule Hannover, 2006. Office: Phone: 0049-(0)511- 953-8621; 0049-(0)511-953-8664 Fax: 0049-(0)511-953-8675 Diagnostic service section - consultation hours: Monday – Friday from 2.30 pm – 4.30 pm; phone: 0049-(0)511-953-8622 Aerial photography: Department of Pathology.  |  Streptococcus (S.) suis is an invasive porcine pathogen causing meningitis, septicemia, arthritis and other diseases. Trends Microbiol. vet.) vorgelegt von Julia Menzel Stuttgart Hannover 2010 . 2015 Mar 30;10(3):e0121586. It is often referred to as TiHo by its staff and students. Willemse N, van der Ark KCH, Stockhofe-Zurwieden N, Smith H, Picavet DI, van Solt-Smits C, Wisselink HJ, Schultsz C, de Greeff A. Sci Rep. 2019 Oct 28;9(1):15429. doi: 10.1038/s41598-019-51576-0. Epub 2005 Aug 25. Biological activities of suilysin: role in Streptococcus suis pathogenesis. Canine distemper virus (CDV) belongs to the genus Morbillivirus of the Paramyxoviridae family. Bacteriological culture and immunohistochemistry of the brain confirmed association with the S. suis challenge strains in all cases with clinical manifestations. 2006 Jun 15;115(1-3):117-27. doi: 10.1016/j.vetmic.2005.12.013. Stiftung Tierärztliche Hochschule Hannover. NIH Andrea Düngelhoef, Sophie Gschaider, Jana Seele, Nadine Büttner, and Christoph Hirche are acknowledged for their excellent work during their practicals. vet. NLM Transcriptome analysis of the Capra hircus ovary. Arwid Daugschies Institut für Parasitologie Veterinärmedizinische Fakultät der Universität Leipzig 2. Abteilung für Experimentelle Pathologie, Dr. Karl Thomae GmbH, Biberach/Riß, und Institut für Pathologie, Abteilung für Immunpathologie, Tierärztliche Hochschule Hannover, Hannover, BRD See all articles by this author. doi: 10.1371/journal.pone.0152675. 2000 Feb;99(2):138-46. doi: 10.1007/pl00007417. (1)Institut für Pathologie, Tierärztliche Hochschule Hannover, 30559 Hannover, Germany. 2014 Jul 2;6(7):2571-601. doi: 10.3390/v6072571. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. See 3 photos and 3 tips from 80 visitors to Tierärztliche Hochschule Hannover. Ligation of CD44 in the early phase may induce chemokines and cytokines and hence initiate and perpetuate the inflammatory process. NCI CPTC Antibody Characterization Program. Would you like email updates of new search results? "Perfect place to start a veterinary career" doi: 10.1371/journal.pone.0121586. 1 Klinik für kleine Klauentiere, forensische Medizin und Ambulatorische Klinik, Stiftung Tierärztliche Hochschule Hannover › Author Affiliations. HHS Toward Understanding the Genetic Basis of Yak Ovary Reproduction: A Characterization and Comparative Analyses of Estrus Ovary Transcriptiome in Yak and Cattle. Institut für Pathologie, Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, D‐3000 Hannover 1Search for more papers by this author. Thus, intravenous application of this serotype 9 strain is required to evaluate heterologous protection in the course of vaccine development based on serotype 2 strains in the future. Epub 2018 May 21. Research topics. In summary, CD44 and MMPs might be associated with the onset of demyelination and may interact to initiate ECM disturbances.  |  2009 Dec 15;132(2-4):135-45. doi: 10.1016/j.vetimm.2009.05.009. Pathogenesis and immunopathology of systemic and nervous canine distemper. Epub 2017 Nov 28. Abstract; Full Text; References Buy Article Permissions and Reprints. USA.gov. Interestingly, expression of MRP within meningitis lesions was demonstrated for both pathotypes via immunohistochemistry. vet. Tenenbaum T, Asmat TM, Seitz M, Schroten H, Schwerk C. Future Microbiol. Heredity (Edinb). COVID-19 is an emerging, rapidly evolving situation. PLoS One. Rieckmann K, Seydel A, Klose K, Alber G, Baums CG, Schütze N. Vaccine X. 2019 Nov 20;8(4):249. doi: 10.3390/pathogens8040249. Clipboard, Search History, and several other advanced features are temporarily unavailable. Clinical examination revealed a 15 × 20 × 15 cm firm … Gutachter: Univ.-Prof. Marion Hewicker-Trautwein und PD Dr. med. The working group „Behavioural ecology and conservation genetics“ aims to understand the factors, that drive and influence the evolution of social structures, the demographic composition, ecological niche construction, distribution, connectivity and the survival of populations. Up-regulation of the hyaluronate receptor CD44 in canine distemper demyelinated plaques. Yang J, Li X, Cao YH, Pokharel K, Hu XJ, Chen ZH, Xu SS, Peippo J, Honkatukia M, Kantanen J, Li MH. Institute of Microbiology and Infectious Diseases of Animals, School of Veterinary Medicine, Hannover, Germany. Institut für Pathologie, Tierärztliche Hochschule Hannover › Author Affiliations › Further Information.
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