It hit the U.S. market in 1993 for the treatment of major depression, but is also prescribed for various anxiety disorders and phobias. Some people report experiencing "brain shivers" or “brain zaps” when they are late taking their prescribed dose of Effexor.2 People often describe these sensations as a very brief, repetitive electric shock-like feeling that remains confined to the brain or head. There is an extensive amount of scientific literature to support the usage of Effexor as a first-line intervention for anxiety disorders.  Nearly every study investigating venlafaxine as a treatment for anxiety disorders have noted its superior therapeutic efficacy when compared to a placebo.  Moreover, there don’t appear to be any limitations associated with research of venlafaxine as an anxiolytic – studies are well-designed, sample sizes are large, and the resulting evidence is robust.  Included below is a brief synopsis of the evidence. Still want to die. Opioidergic effects: Newer evidence suggests that venlafaxine is an indirect opioid receptor modulator.  In animal research, venlafaxine administration appeared to exhibit a dose-dependent analgesic effect, resulting in attenuation of pain responses.  It is unclear as to what extent opioidergic neurotransmission is affected among humans taking Effexor, but it may contribute to an anxiolytic effect. The FDA has approved Effexor for the treatment of various types of anxiety disorders including: generalized anxiety disorder (GAD), panic disorder, and social phobia.  Emerging evidence highlights the therapeutic potential of Effexor for the treatment of additional anxious subtypes including: hoarding disorder, OCD, and PTSD.  In fact, some trials suggest that Effexor is capable of improving OCD symptoms among individuals who derived no therapeutic benefit from a previous SSRI trial.  I speculate that this mechanism was a poor fit for my overall neurophysiology, especially considering that I hadn’t responded to any SSRI/SNRI (other than Paxil) that I tested. Increased anxiety at dose of 225 mg and most likely even less. 2007: Efficacy and safety of extended-release venlafaxine in the treatment of generalized anxiety disorder in children and adolescents: two placebo-controlled trials. What’s more is that Effexor’s propensity to inhibit the norepinephrine transporter (NET) at high doses indirectly increases dopaminergic transmission in the prefrontal cortex.  It is known that some individuals may experience anxiety as a result of poor dopamine signaling and/or low dopamine.  For this reason, it is necessary to speculate that increasing dopamine to a modest extent (among high-dose users), could (subtly) contribute to an anxiolytic effect. In the second study, significant reductions in anxiety were noted from weeks 1 to 8.  Some adverse effects such as: dry mouth, dizziness, insomnia, nausea, and sleepiness were reported; leading to discontinuation in 11% of patients.  That said, this report provides evidence to support the usage of Effexor XR (75-225 mg/day) to attenuate symptoms of anxiety among individuals with major depression. Its hard to be relaxed enough to fall asleep. I’m assuming it will continue to dissipate as my body is still in the adjustment phase. Although Effexor may not be an optimal intervention for all users, there is ample evidence to support its usage as a treatment for anxiety disorders.  Individuals who fail to derive benefit from SSRIs and/or are struggling with anxious-depression – may respond well to Effexor XR.  Effexor is well-researched and understood to be the only SNRI capable of attenuating both depressive and anxious symptoms. They were working, put it seems they've stoped. first on 37.5mg and then 75mg + combo of welbutrin 150mg for the last couple months when i felt that i was starting to get paranoia again. Effexor (Venlafaxine) is a drug that was introduced in 1993 as a pharmaceutical antidepressant by Wyeth; its marketing rights are now owned by Pfizer.  Pharmacodynamically, it functions primarily as a serotonin-norepinephrine reuptake inhibitor (SNRI) and is understood to be the first-ever “dual reuptake inhibitor” approved by the FDA for the treatment of major depressive disorder.  Unlike selective-serotonin reuptake inhibitors (SSRIs) which solely modify serotonin levels, Effexor simultaneously increases extracellular levels of both serotonin and norepinephrine. somnolence, cholesterol increases, height/weight changes) – researchers concluded that Effexor XR was effective and well-tolerated for pediatric GAD. Attention Deficit Disorder. A study by Silverstone and Ravindran (1999) compared the efficacy of Effexor XR to Prozac among individuals diagnosed with depression and anxiety.  They set-up a trial with a double-blinded, randomized, placebo-controlled design and recruited 359 patients that had been diagnosed with major depression and comorbid anxiety.  All patients were assigned to receive either: Effexor XR, Prozac, or a placebo – for a duration of 12 weeks. Although the odds are technically in your favor that Effexor will improve an anxiety disorder (as supported by the research), favorable odds don’t equal universal efficacy and tolerability. There is some evidence to suggest that Effexor is an effective intervention for the treatment of PTSD.  A report published by Pae et al. Researchers sought to determine whether Effexor XR may effectively mitigate hoarding behaviors without tolerability issues. Included with this is PTSD, GAD and DID. 1999: Venlafaxine extended release (XR) in the treatment of generalized anxiety disorder. It was troublesome during weeks 3 and 4 but has started to dissipate this past week. It is recommended that patients use the information presented as a part of a broader decision-making process. Venlafaxine (Effexor) – a serotonin-norepinephrine-reuptake inhibitor (SNRI) antidepressant. My other medications, Lexapro and Zoloft, worked fine for my depression but not as well on the anxiety side. Effexor (venlafaxine) is an antidepressant that is generally prescribed in an extended-release form as Effexor XR. 2003: Venlafaxine in treatment-resistant obsessive-compulsive disorder. It was extremely helpful for cognition however. Maybe I could have kept it if there was a more pronounced opioid-mechanism… really sh*tty it got to this. The sensation can be triggered by moving your eyes and is often accompanied by disorientation, tinnitus (ringing in the ears), vertigo, and/or lightheadedness. SSRI with tricylic antidepressant (TCA) This is a popular combination at least in some parts of the world (Reference Rojo, Ros and Agüera Rojo 2005).The rationale of combining an SSRI with a tricylic antidepressant (TCA) arises from two hypotheses. I have been on Effexor XR, 75 mgs for only 5 weeks but I can already say its the most effective medication I’ve ever been on. Individuals receiving the Paxil also experienced a significant reduction in symptoms of social anxiety as compared with the placebo – across both primary and secondary measures.  There were no significant differences in anxiolytic benefit among those taking Effexor XR compared to those taking Paxil.  Both Effexor XR and Paxil were considered safe, effective, and well-tolerated – providing additional evidence to support the usage of Effexor XR for social anxiety disorder. Increases norepinephrine: It is necessary to consider that some individuals with atypical anxiety disorders may benefit from the increases in extracellular norepinephrine as generated by Effexor.  Perhaps the slight increases in norepinephrine (relative to serotonin) provide additional stimulation to improve cognitive processes, energy, and/or motivation – each of which may decrease anxiety.  A subset of individuals with anxiety disorders may complain of “brain fog” and/or relaxation-induced anxiety (from excessive relaxation). If you’ve tried Effexor XR for an anxiety disorder (or are currently taking it), share your experience in the comments section below. All matters regarding your health require medical supervision. ), SNRIs (Effexor, etc. Next post: Valerian For Anxiety Disorders, Previous post: Propranolol For Anxiety Disorders: A Nonselective Beta Blocker. The study is created by eHealthMe from 33 Effexor users and is updated continuously. 2004: Venlafaxine in the treatment of anxiety disorders. assessed the safety and efficacy of Effexor XR as a treatment for generalized anxiety disorder among older patients.  They reviewed evidence from 5 placebo-controlled, double-blind, randomized, parallel-group, multicenter trials to determine Effexor XR’s safety and efficacy among 1,839 older individuals. Effexor (venlafaxine hydrochloride) is indicated for the treatment of major depressive disorder. California Rocket Fuel: Remeron and Effexor Combination, Propranolol For Anxiety Disorders: A Nonselective Beta Blocker, Pantoprazole (Protonix) vs. Omeprazole (Prilosec), Lexapro (Escitalopram) vs. Prozac (Fluoxetine), Pregabalin (Lyrica) vs. Gabapentin (Neurontin). ive been on effexor for about a year and some change. minimal weight gain), and can mitigate comorbid depressive symptoms.  Moreover, it is a well-researched drug and often “kicks-in” (starts working) quicker than other antidepressant anxiolytics. I have my life back. Effexor withdrawals destroyed my life. SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors) are types of antidepressant medication. my paranoia is from cptsd. October 4, 2006 — Extended-release (ER) venlafaxine is beneficial for improving symptoms of posttraumatic stress disorder (PTSD) and depression, according to the results of a 6-month, placebo-controlled trial reported in the October issue of the Archives of General Psychiatry . A study by Saxena and Sumner (2014) tested the efficacy of Effexor XR for the treatment of hoarding disorder.  Hoarding disorder is regarded as a subtype of anxiety disorder (and possible offshoot of OCD) in which individuals are compelled to save unnecessary items.  In previous research, the pharmacological intervention of Paxil (paroxetine) was found to be effective for reducing hoarding behaviors, but it was not well tolerated. The ideas, procedures, and suggestions contained within this work are not intended as a substitute for consulting with a medical doctor. Worked against sluggish cognitive tempo and being able to keep more than one number, or variable in the head. 1998: A meta-analysis of the effects of venlafaxine on anxiety associated with depression. The study is based on venlafaxine hydrochloride (the active ingredients of Effexor) and Effexor (the brand name). Immediate release: -Initial dose: 37.5 mg orally twice a day OR 25 mg orally 3 times a day. What may be traumatic to one person might not be all that traumatic to another. Even at the full doses. Will you have Vascular Graft Occlusion with Nuvaring. Not only did it make me feel more depressed and suicidal, but it worsened my anxiety.  I ended up with severe brain fog, hot flashes, depersonalization, and felt as if I was living in a bad dream.  Between the temperature changes, the worsening of anxiety, and increasingly depressed mood – my experience with Effexor XR was nothing short of nightmarish.  Clearly, not everyone taking Effexor XR has such an awful experience of adverse effects and/or exacerbation of anxiety – many people find it highly beneficial. Learn how your comment data is processed.  Reflecting upon the experience, I now realize that my psychiatrist was trying to help, but we were simply playing another round of “antidepressant roulette” – and my brain lost the gamble (despite favorable odds suggested by the research). Administration Overall ratings: 3.5/5 Results indicated that individuals with depression and comorbid anxiety experienced a significant reduction in anxious symptoms compared to the placebo.  Reductions in anxiety were evidenced by significant decreases on the HAM-D Anxiety/Somatization factor and Anxiety Psychic item scores.  Significant improvements in anxiety scores occurred by week 3 of the study among those receiving Effexor. Research shows that it is also a good choice for people with comorbid PTSD and depression. 1 year). This site uses Akismet to reduce spam. Unlike selective-serotonin reuptake inhibitors (SSRIs) which solely modify serotonin levels, Effexor simultaneously increases extracellular l… I suffered PTSD, Neurotoxicity, medication induced Anhedonia and medication induced ABI. I was put on effexor and Geodon for ptsd. Some reports may have incomplete information. Will you have Dry Eye Syndrome with Soybean? Usual Adult Dose for Depression. (2004) analyzed the efficacy of Effexor, an SNRI as an alternative treatment for OCD. Retrospectively, researchers analyzed the HAM-D results and focused specifically on Anxiety/Somatization factor and Anxiety Psychic item scores.  Of the 6 studies included in this meta-analysis, a total of 3 were placebo-controlled and the remaining 3 were placebo and drug-controlled.  The researchers classified individuals with depression as having comorbid anxiety if their Anxiety Psychic item scores (from the HAM-D) were at least “2.”. A report by Thase (2006) discussed the usage of Effexor XR as a treatment for anxiety disorders.  In the report, it was noted that following the introduction of an XR (extended-release) format of venlafaxine in 1997, the drug received approval as a treatment for several subtypes of anxiety disorders including: generalized anxiety disorder (GAD), panic disorder, and social phobia.  Thase highlighted evidence to suggest that Effexor XR was also likely effective as a treatment for PTSD and OCD. Development of characteristic symptoms following a psychologically traumatic event that is generally outside the range of usual human experience; symptoms include numbed responsiveness to environmental stimuli, a variety of autonomic and cognitive dysfunctions, and dysphoria. 33 people are studied for taking Effexor in Post-traumatic stress disorder. 18.75-75 mg/day; may increase to 150 mg/day after 4 weeks; doses up to 225 mg/day used. Venlafaxine (Effexor): 75 mg to 300 mg daily. -Maximum dose: ---Moderately depressed outpatients: 225 mg/day. 1999: Venlafaxine XR therapy for major depression and anxiety disorders.  Looking back, I speculate that I reacted poorly to both the combined serotonergic and noradrenergic effects elicited by Effexor. 2002: Venlafaxine ER as a treatment for generalized anxiety disorder in older adults: pooled analysis of five randomized placebo-controlled clinical trials.  They recruited 24 individuals diagnosed with hoarding disorder (based on DSM-5 criteria) for an open-label trial.  It should be noted that, prior to this trial, all patients were free of psychiatric medications for at least 6 weeks. (2007) analyzed the safety and efficacy of Effexor XR as a treatment for generalized anxiety disorder (GAD) among children and adolescents.  Although there was evidence to suggest that Effexor was an effective and safe anxiolytic for adults with GAD, additional research was necessary to establish its safety and efficacy among younger individuals.  Researchers recruited 320 individuals (between 6 and 17 years of age) who were diagnosed with generalized anxiety disorder (via the DSM-IV criteria). All anxiolytic improvements were sustained for the entire 6 weeks of treatment, and in a longer study, for a span of 12 weeks.  Although Effexor is already a well-established antidepressant, this meta-analysis provides evidence to support its usage as a monotherapy for cases of depression with concomitant anxiety. Furthermore, one report suggested that Effexor XR was equally as effective as Buspar (an FDA approved anxiolytic) for the treatment of generalized anxiety disorder (GAD).  In fact, when compared head-to-head with Buspar, Effexor XR demonstrated superior efficacy in treating a subset of generalized anxiety disorder (GAD) symptoms.  The author (Sheehan) concluded that Effexor XR is effective and well-tolerated as a treatment for generalized anxiety disorder. I hate going to sleep. Symptoms may include flashbacks, nightmares and severe anxiety, as well as uncontrollable thoughts about the event.Most people who go through traumatic events may have temporary difficulty adjusting and coping, but with time and good self-care, they usually get better. You, as a reader of this website, are totally and completely responsible for your own health and healthcare. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. -- … Post-traumatic stress disorder (PTSD) is a mental health condition that's triggered by a terrifying event — either experiencing it or witnessing it. Effexor (Venlafaxine) is a drug that was introduced in 1993 as a pharmaceutical antidepressant by Wyeth; its marketing rights are now owned by Pfizer. Researchers Bose, Korotzer, and Gommoll (2008) documented the effects of Effexor XR and Lexapro for the treatment of generalized anxiety disorder.  They recruited a large number of participants, each of which were diagnosed with generalized anxiety (based on DSM-IV criteria).  The participants were set to receive either: Lexapro (10 to 20 mg per day), Effexor XR (75 to 225 mg per day), or a placebo (daily) – for a term of 8-weeks. Post-traumatic stress disorder is found to be related to 1,236 drugs and 790 conditions by eHealthMe. You can also subscribe without commenting. Results indicated that symptoms of hoarding disorder were significantly attenuated with administration of Effexor XR.  Average scores on the SI-R decreased by 32% and average scores on the UHSS decreased by 36%.  Of the 23 individuals that finished the study, 70% were thought to derive significant therapeutic benefit from Effexor XR.  This provides preliminary evidence to suggest that Effexor XR may be a viable pharmaceutical for individuals with hoarding disorders, a subtype of anxiety disorder. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Others report the sensation spreads out to other parts of the body. One medication used for serotonin and norepinephrine reuptake inhibition is venlafaxine extended release (Effexor XR), which has been shown to … Despite the fact that Effexor is an older medication from the 1990s, it is still regarded as a clinically effective pharmacological intervention for the treatment of anxiety disorders.  Many individuals prefer Effexor over other antidepressants for anxiety because it has a favorable side effect profile (e.g. Effexor has active ingredients of venlafaxine hydrochloride. Effexor XR (Venlafaxine) is an Effective Treatment for PTSD!! Nearly every published study analyzing the efficacy of Effexor as a treatment for anxiety has discovered it to be therapeutically effective.  In all published placebo-controlled studies, Effexor demonstrated superior anxiolytic efficacy over placebos.  Additionally, in drug-controlled studies, Effexor was found to be of equal efficacy to already-approved pharmaceutical agents such as Paxil, Buspar, and clomipramine for the treatment anxiety disorders. It was known that Effexor XR is a safe, effective treatment for generalized anxiety disorder among adults, but safety and efficacy haven’t been specifically investigated among older adults.  An analysis published in 2002 by Katz et al. The one constant is the effects, such as anxiety, anger, depression, etc. A study published by Il’ina (2009) examined the efficacy of venlafaxine among 30 individuals diagnosed with “anxious-depression.”  Of the 30 individuals, 7 were male and 23 were female, and 24 were treated on an inpatient basis, while 6 were treated as outpatients.  All patients received venlafaxine for an 8-week period at dosages ranging from 225 mg to 375 mg. Lipov E and Kelzenberg Briana. 2014: Venlafaxine extended-release treatment of hoarding disorder. The use of the eHealthMe site and its content is at your own risk. -Maintenance dose: 75 to 150 mg orally per day, given in divided doses. A large-scale trial conducted by Allgulander et al. Notify me of followup comments via e-mail. Different individuals may respond to medication in different ways. Sertraline is also used to treat obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). It is documented that up to 40% of individuals diagnosed with OCD derive insignificant therapeutic benefit from SSRIs.  Although SSRIs are an effective first-line option, other pharmacological options are necessary to treat the 40% of non-responders.  For this reason, researchers Hollander et al. If you’re a long-term Effexor XR user, has the drug maintained its anxiolytic efficacy?  Have you had to increase the dosage as a result of dwindling anxiolytic efficacy over an extended duration?  If you’ve had to increase your dosage due to tolerance, note how long it took (e.g. For instance, I've been diagnosed with PTSD and a sudden loud noise really gets to me. (2002) assessed the efficacy of Effexor compared to clomipramine (a tricyclic antidepressant) for the treatment of OCD.  For the trial, researchers recruited a total of 73 patients that had been diagnosed with OCD (based on DSM-IV criteria).  Of the 73 participants, a total of 26 received Effexor (225-350 mg/day) and 47 received clomipramine (150-225 mg/day) for a duration of 12 weeks. 2004: Efficacy of Venlafaxine ER in patients with social anxiety disorder: a double-blind, placebo-controlled, parallel-group comparison with paroxetine. Wyeth scientists -- John Yardley, Morris Husbands, and Eric Muth -- recognized venlafaxine’s promise as an important antidepressant and pressed forward with its development. Effexor, also known as venlafaxine, is an antidepressant medication. I’m amazed that I’m doing better on the starting dose of Effexor than I was on the full doses of the others. Some medications are more notorious for this symptom than others. 2006: Treatment of anxiety disorders with venlafaxine XR. Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. (2007) suggested that the pathophysiology of PTSD is associated with dysfunction of serotonin and norepinephrine.  In this report, researchers speculated that Effexor administration may normalize monoaminergic dysfunction associated with PTSD. Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison. The phase IV trial will monitor drug safety outcomes that … I shall not be liable or responsible for any loss or damage allegedly arising from any information or suggestions within this website. Celexa (Citalopram) vs. Lexapro (Escitalopram): Which Is Better? © MentalHealthDaily.com 2013-2019 | Privacy Policy | Legal Notice | Affiliate Disclosure. Will you have Bone Marrow Oedema Syndrome with Letrozole? A trial conducted by Rynn et al. The study was randomized, double-blinded, and placebo-controlled.  Throughout the trial, severity of generalized anxiety was measured with the Hamilton Anxiety Scale (HAM-A).  The chief parameter for determining efficacy of each intervention was the average change in HAM-A scores after the 8-week term compared to baseline. A study conducted by Allgulander, Hackett, and Salinas (2001) documented the safety and efficacy of Effexor XR as a treatment for generalized anxiety disorder (GAD).  For the study, researchers recruited 541 individuals (ages 18 to 86) for a placebo-controlled, double-blinded, fixed-dose trial.  Individuals were set to receive either: fixed doses of Effexor XR (37.5 mg, 75 mg, 150 mg – per day) or a placebo – for a period of 24 weeks.
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